Guadalajara safety is similar to what you would find in most large cities. Crime in Mexico varies widely by location with the worst crime reported in the states that border the United States and the south of Mexico, mostly because of drug cartel activity, according to the U.S. Department of State.
The U.S. Department of State’s Bureau of Diplomatic Security (OSAC), however, reported multiple homicides, assaults, robberies and car thefts in Guadalajara. Official 2015 police statistics showed a decrease in most of the major crime categories, but homicides increased by 50 percent. The city also has a reputation for illicit money transactions. Legitimate business and drug trafficking organization (DTO) activity can intermingle, the police reported.
The U.S. government also issued travel warnings for the state of Jalisco, primarily on its borders with the states of Michoacan and Zacatecas. The U.S. government has advised its personnel to use the Federal toll road 15D for travel to Mexico City, but stops in La Barca or Ocotlan are not permitted. Travel on Highway 80 between Cocula and La Huerta is not permitted for U.S. government personnel.
You can also stay updated on travel warnings and safety information at this U.S. Department of State website.